Streptozotocin Generates Peroxynitrite Luminescence Which Reveals the Probable Cause of Diabetes 1,2 and 3 (Alzheimer’s disease)

The fundamental basis of diabetes continues to go unrecognized and untreated. Depending on the type of diabetes i.e; 1 or 2, treatment consists of insulin injections (1) or antidiabetic drugs that lower blood glucose and hopefully hemoglobin A1C as well (2) Often patients with type 2 are asked to lose weight, exercise more vigorously as well and more frequently. Previously, using a diabeticstreptozotocin (STZ) rat model, we demonstrated that diabetes and cataracts could be entirely prevented using equimolar amounts of STZ and a nitric oxide oxidizing compound called sodium carboxy-PTIO. This indicated that STZ generated a nitric oxide –oxygen based toxin that could be destroyed in vivo. The treatment completely prevented STZ from increasing blood glucose and all the signs of diabetesincluding cataracts were prevented. Later work indicated how the STZ-diabetes pathway was likely created. Now, we demonstrate that STZ actually generates the oxidizing and nitrating peroxide known as peroxynitrite (OONO-). In the cases of diabetes 1,2 most or all of many anti-diabetic drugs only control the level of blood glucose, and many with considerable side effects. We demonstrate in diabetic children over a three year period that even with tight dietary control of blood glucose, diabetes still persists. This diabetic damage stems from peroxynitrite. Using STZ to generate peroxynitrite in animals, we demonstrate that a variety of nitration targets can diminish peroxynitite which is the most important step in controlling both diabetes and possibly Alzheimer’s disease since recent data links diabetes and Alzheimer’s disease.